Yes, I'm using pipelines. From my playout system (Station Playlist) to Pipeline 1 into BreakawayOne. I am not sure why remote desktop would have anything to do with audio, unless it was "stealing" the audio from your radioDJ and blocking it from BaOne… I think you can disable all audio from Remote Desktop. Or, if you're using something other than Kernel Streaming in your input/output, that could be an issue. Selecting Kernel Streaming is also a way to lock down the audio channels from other things using them.