I’ve done some more research on this on the VAC website. In one section, it says that low numbers should be avoided, but elsewhere it says “The more is event frequency, the shorter is event period, the less is block size, the smoother is stream transfer, and the less is latency. But decreasing interrupt/event period causes increase of system timer resolution and timer interrupt frequency so system overhead is increased too. VAC driver sets system timer resolution to a half of the “MS per int” parameter specified.
Large (more than 10-15 ms) values may significantly disrupt stream uniformity and even cause stream breaking.”
I guess if you have a “grunty” PC, low (1 to 5) will work OK, but throw a greater load on the OS. Higher (10-15) may reduce the OS load, but could let too many other events get in the way of a smooth stream.