Beyond the obvious, that you should make sure "Bypass" isn't enabled…
Breakaway's input should be the Breakaway Pipeline, and the output should be your Realtek Speakers output. You should also set the default communications soundcard to be the Breakaway Pipeline to make sure nothing uses the Realtek by default.
Also make sure any volume controls in the audio path before Breakaway are turned up all the way, so that Breakaway has enough signal to work properly. To control the output levels, I recommend a combination of Breakaway's Volume control, and when that's all the way up to 0dB (maximum output level), setting the Realtek Speakers level in the properties for that soundcard's playback so that it gets as loud as it can without distorting whatever's hooked up to it (or as loud as you'd ever possibly want it), and then turning it down just a little from that setting.

And of course, if the program that you want to run through Breakaway isn't going through it, make sure it's set to either use the default soundcard, or to use Breakaway Pipeline. Two ways of doing the same thing.